Abstract: Numerous studies have examined the genetic association of vascular endothelial growth
factor (VEGF) single nucleotide polymorphisms (SNPs) with recurrent pregnancy loss (RPL). However,
of the four known SNPs in the 30-untranslated region (30-UTR) of VEGF, three SNPs—namely rs3025040
(1451C>T), rs10434 (1612G>A), and rs3025053 (1725G>A)—remain poorly characterized with regard
to RPL. Herein, we evaluated the association between these three SNPs in the VEGF 30-UTR and RPL
susceptibility. We analyzed VEGF 30-UTR gene variants in with and without RPL using TaqMan
allelic discrimination. There were significant dierences in the genotype frequencies of 1612G>A
(GA: adjusted odds ratio (AOR), 0.652; 95% confidence interval (CI), 0.447–0.951; p = 0.026) and
1725G>A (GA: AOR, 0.503; 95% CI, 0.229–0.848; p = 0.010) in RPL patients vs. controls. Our results
indicate that the 1612G>A and 1725G>A polymorphisms in the 30-UTR of VEGF are associated with
RPL susceptibility in Korean women. These data suggest that VEGF 30-UTR polymorphisms may be
utilized as biomarkers for the detection of RPL risk and prevention